DNA纳米生物技术

课程编码：1801010703I0P1005Y 英文名称：DNA Nanobiotechnology 课时：40 学分：2.00 课程属性：学科核心课 主讲教师：赵健等

This course will focus on the concept, construction, and application of DNA nanobiotechnology, and particularly the impact of DNA nanobiotechnology on the diagnosis and drug delivery. Topics include of the basics of DNA nanobiotechnology, molecular diagnosis, and therapeutic applications. Through this course, you will understand how to apply DNA nanobiotechnology to diagnostic testing and pharmaceutical research. Prerequisites: Some background in biology or chemistry will be helpful.

Basic knowledge of college chemistry,Basic knowledge in general biology

第一章 Introduction of DNA nanobiotechnology 6.0学时
第1节 DNA nanobiotechnology: synthesis and properties
第2节 Functional DNA for biorecognition and targeting
第二章 DNA nanobiotechnology for diagnosis 12.0学时
第1节 DNA nanobiotechnology for liquid biopsy
第2节 DNA nanobiotechnology for cellular imaging
第3节 DNA nanobiotechnology for in situ imaging in vivo
第4节 Flipped classroom
第三章 DNA nanobiotechnology for drug delivery 15.0学时
第1节 DNA nanobiotechnology for delivery of small molecular drugs
第2节 DNA nanobiotechnology for gene delivery
第3节 DNA nanobiotechnology for delivery of therapeutic proteins
第4节 DNA nanobiotechnology for delivery of multiple drugs
第5节 Flipped classroom
第四章 DNA nanobiotechnology for theranostics 4.0学时
第1节 DNA nanobiotechnology for theranostics
第2节 Flipped classroom
第五章 Final examination 3.0学时
第1节 Final examination

Jian Zhao is an associate professor of DNA nanotechnology at the National Center for Nanoscience and Technology (NCNST). He received his PhD from the Institute of Microbiology, Chinese Academy of Sciences (CAS) in 2016. His research interests focus on the development of biosensors for activatable molecular imaging. He has published more than 30 papers in high ranked journals, including Nat.Biomed. Eng., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Sci. Adv. ; Mengyuan Li is a professor in the University of Science and Technology Beijing. She received her Ph.D. degree from Peking University (under the supervision of Prof. Song Gao and Prof. Zheming Wang) and then worked as a postdoctoral research fellow at University of Notre Dame (with Prof. Slavi C. Sevov) and Harvard Medical School (with Prof. Daniel S. Kohane and Prof. Robert Langer). Her research interests focus on protein recognition regulation, analysis and biosensors.