表观遗传学

课程编码：1801010710I0P1010Y 英文名称：Introduction to Epigenetics and RNA Silencing 课时：60 学分：3.00 课程属性：学科核心课 主讲教师：张晓明等

Epigenetics and RNA silencing are two of the hottest topics in the past two decades. Epigenetics is the study of heritable changes in gene expression that do not change DNA sequence.RNA silencing is a general regulation mechanism in eukaryotes that regulates gene expression by 20-30 nt sRNAs in transcription or post-transcription levels. In this Epigenetics, we will introduce how DNA methylation, histone modification, chromatin remodeling, long non-coding RNAs and RNA modification regulate gene expression in eukaryotes. In the second part, we will study RNA silencing on sRNA generation, amplification, loading, action, turnover, and function. The most popular technologies used in Epigenetic studies and non-coding RNAs will also be discussed.

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第一章 General Introduction to Epigenetics and Non-coding RNA 3学时 张晓明
第1节 Course information
第2节 Introduction to epigenetics
第3节 Introduction to small non-coding RNAs, long non-coding RNAs and circular RNAs
第二章 DNA Methylation and Imprinting 3学时 钱伟强
第1节 Overview to DNA methylation
第2节 Function of DNA methylation
第3节 Techniques for determine the DNA methylation level
第4节 Transposon silencing and imprinting
第三章 DNA Demethylation 3学时 钱伟强
第1节 Passive DNA demethylation
第2节 Active DNA demethylation
第3节 Fuction of DNA demethylation
第四章 Histone Modification and Histone Variation 6学时 王宪辉
第1节 Overview of histone modifications
第2节 Specific modifications of histone and their functions
第3节 Techniques to study histone modifications
第4节 Overview of histone vaiation
第5节 Phenotypic plasticity ragulated by epigenetics
第五章 Chromatin Remodeling and Epigenetics related disease 3学时 张晓明
第1节 Overview of chromatin remodeling
第2节 Function of chromatin remodeling
第3节 Epigenetics related disease
第六章 Non-coding RNA 30学时 张晓明
第1节 Discovery of non-coding RNA
第2节 Processing of small non-coding RNA
第3节 Replication of small non-coding RNA
第4节 Action of of small non-coding RNA
第5节 Function of small non-coding RNA
第6节 Transcription and action of long non-coding RNA
第7节 Functions of long non-coding RNA
第8节 Overview to circular RNA and their function
第9节 RNA modifications
第10节 Methods in non-coding RNA study
第七章 Transgenerational Epigenetic Inheritance 3学时 张晓明
第1节 Overview to inheritance
第2节 Mendel inheritance and transgenerational epigenetic inheritance
第3节 Mechanism of transgenerational epigenetic inheritance
第八章 Bioinformatics Tools to study Epigenetic and Non-coding RNA 3学时 张晓明
第1节 Bioinformatics tools for epigenetic modification
第2节 Bioinformatics tools for noncoding RNA
第九章 Summary & Review 3学时 张晓明
第1节 Summary & Review
第十章 Final examination 3学时 张晓明
第1节 Final examination

Xiaoming Zhang is a professor at the Institute of Zoology, Chinese Academy of Sciences. He received his Ph.D. degree from Peking University. Currently, his research focuses on the interaction among pathogens, hosts, and insect vectors in the field of molecular biology, with a particular emphasis on the role of non-coding RNA in host antiviral defense.

Xianhui Wang is a professor at the Institute of Zoology, Chinese Academy of Sciences. He earned his Ph.D. degree from the Institute of Zoology, Chinese Academy of Sciences. His dedication lies in understanding behavioral plasticity involved in group living, employing '-omics' technologies in two study models: locusts and bumblebees.

Weiqiang Qian, a professor in the School of Advanced Agricultural Sciences at Peking University, obtained his Ph.D. degree from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences. His current focus is on plant epigenetics, specifically the molecular mechanisms of active DNA demethylation and transcriptional gene silencing (TGS), as well as the function of noncoding RNA-protein complexes in plants.