生物化学

课程编码：1801010710I0P1008Y 英文名称：Biochemistry 课时：60 学分：3.00 课程属性：学科核心课 主讲教师：钟良玮等

Upon completion of the course, the students should: (1) be familiar with the basic properties and functions of amino acids and proteins, as well as the principle for protein separation, purification, identification; (2) know how to analyze enzyme activity, enzyme kinetics and protein-protein interaction; (3) understand protein synthesis, targeting and modifications; (4) understand the association of abnormal glucose, lipid and amino acid metabolism with diseases; (5) be able to explain connections among carbohydrate metabolism, lipid metabolism and amino acid metabolism; (6) be able to evaluate biochemical literatures and give an oral presentation.

A knowledge on organic chemistry.

第一章 Introduction to Biochemistry 2学时 钟良玮
第1节 Introduction to Biochemistry
第二章 Section A – Amino acids and proteins 8学时 钟良玮
第1节 Amino acids and proteins
第2节 Structures and functions of proteins
第3节 Purification of proteins
第三章 Section B – Enzymes 4学时 钟良玮
第1节 Properties of enzymes
第2节 Factors affecting enzyme activity
第3节 Enzyme kinetics and inhibition
第四章 Section C – Protein synthesis, targeting, modifications and folding 3学时 钟良玮
第1节 Protein synthesis
第2节 Protein targeting
第五章 Section C – Protein synthesis, targeting, modifications and folding2 6学时 张竹青
第1节 Protein folding and protein structure prediction
第2节 Protein design and structure-based drug design
第六章 Section D – Carbohydrate metabolism 9学时 钟良玮
第1节 Basic properties of carbohydrates
第2节 Metabolic pathways
第3节 Digestion and absorption
第4节 High glucose and oxidative stress
第七章 Section E – Lipid metabolism 8学时 钟良玮
第1节 Structure and roles of lipids
第2节 Fatty acid breakdown and synthesis
第3节 Cholesterol metabolism
第4节 Lipoproteins
第八章 Section F – Nitrogen metabolism 7学时 钟良玮
第1节 Nitrogen fixation and assimilation
第2节 Amino acid metabolism
第3节 Urea cycle
第九章 Section G — Electron Transport and Oxidative Phosphorylation 6学时 钟良玮
第1节 The electron transport chains
第2节 Oxidative phosphorylation.
第十章 Section H ̶ a project work 4学时 钟良玮
第1节 Student Literature Presentation
第十一章 Section I ̶ Final examination 3学时 钟良玮
第1节 Final examination

Liangwei Zhong, Prof. PhD.
Graduated from the Karolinska Institute in Sweden, and has been engaged in biochemical teaching and related research for decades.
Dr. Zhuqing Zhang, Professor, College of Life Sciences, University of Chinese Academy of Sciences.