纳米生物传感与检测

课程编码：1801010710I0P1011Y 英文名称：Nanobiological Sensing and Detection 课时：60 学分：3.00 课程属性：学科核心课 主讲教师：李乐乐等

Biosensing and imaging using nanomaterials and nanotechnology has the potential to revolutionize scientific research and medical diagnostics. This course will focus on the principles, construction, and application of Nano-biosensing and imaging systems, and particularly the impact of nanotechnology on the development of biosensors. The course will be started with an introduction of the solid background on the nano-biological sensors, bioimaging, nanomaterials and nanotechnology, biorecognition units, biomarkers, and disease diagnostics. Then, examples of biosensing and imaging systems created from various nanomaterials are introduced, including fluorescent/luminescent nanoparticles, magnetic nanoparticles, carbon nanomaterials, gold nanoparticles, porous materials, and DNA nanostructures, with a distinct emphasis on the need to tailor nanosensor designs to specific biotargets. The topic of cancer-specific nano-biosensors will also be addressed and discussed to provide deep insight into the recent advances of using nano-biosensors for disease diagnostics and therapy.

College Chemistry, College Materials, English.

第一章 Introduction of nano-biosensing and imaging 6.0学时
第1节 Concept of nano-biosensing and imaging
第2节 Introduction of nanomaterials used for biosensing and imaging
第二章 Nano-bio interface for biosensing and imaging 6.0学时
第1节 Surface functionalization strategies of nanomaterials
第2节 Surface engineering of nanomaterials for overcoming biological barriers
第三章 Fluorescent nanomaterials for biosensing and imaging 9.0学时
第1节 Quantum dots-based fluorescent biosensing and imaging
第2节 Lanthanide ions-doped nanomaterials for fluorescent biosensing and imaging
第3节 Fluorescent biosensing and imaging based on aggregation-induced emission
第四章 Porous nanomaterials for biosensing and imaging 6.0学时
第1节 Mesoporous silica-based biosensing and imaging
第2节 Metal-organic frameworks-based biosensing and imaging
第五章 Other nanomaterials for biosensing and imaging 12.0学时
第1节 Gold nanomaterials-based biosensing and imaging
第2节 Magnetic nanomaterials-basesd biosensing and imaging
第3节 Carbon nanomaterials-based biosensing and imaging
第4节 DNA nanomaterials-based biosensing and imaging
第六章 Combination of biosensing/imaging with drug delivery 6.0学时
第1节 Introduction of nanomedicine
第2节 Combination of biosensing/imaging with nanomedicine for theranostics
第七章 Flipped Classroom 12.0学时
第1节 Flipped Classroom
第八章 Final examination 3.0学时
第1节 Final examination

Lele Li joined the National Center for Nanoscience and Technology as a professor in 2016. He received his Ph.D. degree at Peking University and then worked as a postdoctoral research fellow at UIUC, Harvard Medical School and MIT. His research interest includes the development of sensor technology for in situ molecular imaging.