合成生物学导论

课程编码：1801010710I0P1015Y 英文名称：Introduction to synthetic biology 课时：40 学分：2.00 课程属性：学科核心课 主讲教师：于龙江等

Synthetic biology, a new interdisciplinary field of science, brings together biologist, chemist and physicist to tackle the challenge that how molecular interactions inside the cell work in concert to produce a cellular function. This course will introduce the basic concepts and principles of synthetic biology, which is loosely defined as the construction and reconstruction of biological systems, and its practical applications in research and industry. Basic principles, advanced molecular biology tools for DNA assembly, the construction of biological pathways and circuits, genome editing, strategies for transcriptional control and mathematical modelling will be examined in the course. Students enrolled in this course will be able to understand the basic concepts and the importance of synthetic biology; grasp the scientific frontier of synthetic biology; acquire the advanced molecular biology techniques that facilitate the building of biological parts and systems; understand and describe biological parts and their functions on a systems-level; understand the approaches to characterize and regulate the combinations of different biological parts and systems; learn how to design and optimize models with the aid of computer; learn how to apply synthetic biology to different fields.

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第一章 Introduction of synthetic biology 3.0学时 于龙江
第1节  Origin and development of synthetic biology
第2节 Emergence process of synthetic biology
第3节 Engineering characteristics and research areas of synthetic biology
第二章 Principles of synthetic biology 7.0学时 于龙江
第1节 Thoughts on the analysis of synthetic biology
第2节  Standardization and quantification of blocks
第3节  Hierarchical structure of synthetic biological system
第4节 Logical structure of synthetic biological system
第5节  Quantitative research method of synthetic biological system
第6节 Design principle and simplicity of synthetic biological system
第7节 Design principle of new synthesis reaction and network
第三章 Gene Circuit of Synthetic Biological System 5.0学时 于龙江
第1节  Overview of gene circuit
第2节  Regulatory elements of gene circuit
第3节 Logic gate of gene circuit
第4节  Switch of gene circuit
第5节 Regulatory mode of gene circuit
第6节 Examples of gene circuit
第四章 Design and assembly of synthetic biological system 6.0学时 于龙江
第1节 Design of synthetic biological system
第2节 Assembly and construction of synthetic biological system
第3节 Global regulation and optimization of synthetic biological system at the genetic level
第4节 Analysis and screening of synthetic biological system
第5节 Characteristic cycle of “Design-Construction-Examination-Redesign”
第6节 Interactions between bacteria in synthetic biological system
第五章 Regulation and optimization of synthetic biological system 4.0学时 于龙江
第1节 Local regulation and optimization of synthetic biological system
第2节 Global regulation and optimization of synthetic biological system at the genetic level
第3节 Rational and random adjustment of synthetic biological system
第六章 Cell-free synthetic biological system 5.0学时 于龙江
第1节 Concept and design principle of cell-free synthetic biological system
第2节 Classification of cell-free synthetic biological system
第3节 Engineering modification of cell-free synthetic biological system
第4节 Engineering application of cell-free synthetic biological system
第七章 Mathematical modeling and synthetic biology 6.0学时 田利金
第1节 Introduction
第2节 Basic methods of mathematical modeling for synthetic biology system
第3节 Analysis and evaluation of mathematical models of synthetic biology
第4节 Basic mathematical models of synthetic biology
第5节 Database design and modeling in the era of big data
第6节 Applications of computer technology in synthetic biology
第八章 Practical applications of synthetic biology 5.0学时 田利金
第1节 Applications in “green” chemical engineering
第2节 Applications in environmental improvements
第3节 Applications in medical science
第4节 Applications in stress resistances enhancement
第5节 Other applications
第九章 New trends and disruptive innovations in synthetic biology 4.0学时 田利金
第1节 synthetic biology: global strategy and economic benefits
第2节 Risks and potential rewards of synthetic biology
第3节 synthetic biology: world research centers and the state of the art
第4节 synthetic biology: safety and ethics
第十章 Lab Tour 3.0学时 田利金
第1节 Lab Tour
第十一章 Exam 2.0学时 于龙江
第1节 Exam

于龙江博士，2011年在日本茨城大学获得博士学位并继续开展博士后研究，2014-2018年在日本冈山大学担任助理教授，入选国家海外人才计划青年项目，长期从事光合作用原初反应的分子机制研究。田利金博士，2013年在荷兰瓦格宁根大学获博士学位。2013-2018年，先后在阿姆斯特丹自由大学，荷兰莱顿大学开展博后工作，科学院BR计划获得者， 现任中科院植物研究所植物光能转化与调控研究组组长，长期从事光合作用过程中光能的吸收及转化的物理分子机制及动力学研究。