基础免疫学

课程编码：0710I0D01004H 英文名称：Fundamental Immunology 课时：52 学分：3.00 课程属性：一级学科核心课 主讲教师：方敏等

Fundamental Immunology is designed as a comprehensive course of immunology for research postgraduates in biology field. The class will give students a general view of immunology and some detailed development in certain selected area of immunology. As a course for postgraduates research case studies are incorporated into the course to provide examples for researches carried out in respective fields. This course covers the components of the immune system, Innate immunity, the cell biology of antigen processing and presentation, antibody and B cells, T cell response, the molecular structure and assembly of MHC molecules, and the pathogenesis of immunologically mediated diseases and immune system as defense system against infectious disease and tumor, and immunology as tool for general biology including antibody technology and flow cytometry. The course is structured as a series of lectures and mini-seminars in which individual research cases are discussed with faculty tutors.

Immunology, Cell Biology, Microbiology，Virology

第一章 Introduction of Immunology 4学时 方敏
第1节 Introduction of Immunology
第2节 General Properties of Immune Responses
第3节 Cells and Tissues of the Immune Systems
第4节 The development stages of Immunology
第二章 Innate Immunity 4学时 方敏
第1节 Features of Innate Immune Recognition
第2节 Components of the Innate Immune System 1
第3节 Components of the Innate Immune System 2
第4节 The Intersection of Innate and Adaptive Immunity
第三章 NK cell development and function 4学时 方敏
第1节 General properties of NK cells
第2节 NK cell development and differentiation
第3节 NK cells in anti-viral immunity
第4节 Memory NK cells
第四章 Immunoglobulins and B lymphocytes 4学时 方敏
第1节 Immunoglobulins: Structure and Function
第2节 Antigen-antibody interactions and Monoclonal Antibody
第3节 B lymphocytes Development and Biology
第4节 B lymphocytes Signaling Mechanisms and Activation
第五章 T lymphocytes 4学时 方敏
第1节 T cell Antigen Receptors
第2节 T lymphocyte Signaling Mechanisms and Activation
第3节 Development of T cells
第4节 Peripheral T lymphocyte responses and Function
第六章 Major Histocompatibility Complex (MHC) Molecules and Antigen Presentation 4学时 方敏
第1节 MHC Molecules and Genes
第2节 Regulation of MHC Expression
第3节 Antigen Processing and Presentation 1
第4节 Antigen Processing and Presentation 2
第七章 Immunity to infectious Agents 4学时 方敏
第1节 Immunity to Viruses case study 1
第2节 Immunity to other infectious agents
第3节 Vaccine Designs
第4节 Immunity to Viruses case study 2
第八章 Immunologic Tolerance and Autoimmunity 4学时 段学锋
第1节 B lymphocyte tolerance, and tolerance induced by foreign protein antigens
第2节 T lymphocyte tolerance
第3节 Mechanisms of autoimmunity
第4节 Advances in immunologic tolerance and autoimmunity
第九章 Immunity to Tumors 4学时 段学锋
第1节 Overview and tumor antigens
第2节 Immune responses to tumors and evasion of immune responses by tumors
第3节 Immunotherapy for tumors and the role of innate and adaptive immunity in promoting tumor growth
第4节 Advances in immunity to tumors
第十章 Hypersensitivity Disorders and Allergy 4学时 段学锋
第1节 Mechanisms and classification of hypersensitivity
第2节 Selected immunologic diseases
第3节 Allergic diseases in humans: pathogenesis and therapy
第4节 Advances in hypersensitivity and allergy
第十一章 The Immune system in Disease 4学时 段学锋
第1节 Systemic Autoimmunity
第2节 Transplantation Immunology
第3节 Congenital immunodeficiencies
第4节 cquired immunodeficiencies
第十二章 Immunity in the mucosal system 4学时 方敏
第1节 Overview of the mucosal system
第2节 The mucosal immune system
第3节 Immunity in the mucosal system
第4节 Mucosal diseases and Vaccine design
第十三章 Course Review and Students Final Presentation 4学时 方敏
第1节 Course review and questions
第2节 Students Presentation 1
第3节 Students Presentation 2
第4节 Students Presentation 3

Prof. FANG Min et al.